李加忠

职务/职称：副教授/硕导

研 究 所：药物化学研究所

电子邮件：lijiazhong@lzu.edu.cn

【基本情况】

9193澳门永利场药学院副院长，博士，副教授,硕士生导师。2002年6月毕业于9193澳门永利场化学化工学院国家基础科学研究与教学人才培养基地班，获得理学学士学位。2004年9月开始，在9193澳门永利场化学化工学院分析化学专业硕博连读，并于2009年获得博士学位。2008年10月至2010年4月获得中国国家留学基金委员会的项目资助，赴意大利Insubria大学进行联合培养。

【研究方向】

药物设计与发现、中药方及中药现代化研究等

【主讲课程】

本科生《药物设计学》、《医学统计学》，研究生《计算机辅助药物设计》

【获奖情况】

2013年首届“甘肃省优秀药学工作者”

2015年首届“9193澳门永利场青年五四奖章”

【研究成果】

[1] Lingyan Wang, Jiazhong Li*, Structure-activity relationship analysis of carbobiocyclo and oxabicyclo succinimide analogs as potential androgen receptor antagonists, Journal of Biomolecular Structure and Dynamics, 2017, 35, 1371643.

[2] Hongli Liu, Lingyan Wang, Jiaqi Tian, Jiazhong Li*, Huanxiang Liu, Molecular Dynamics Studies on the Enzalutamide Resistance Mechanisms Induced by Androgen Receptor, Journal of Cellular Biochemistry, 2017, 118, 2792-2801.

[3] Yuwei Wang, Rui Han, Huimin Zhang, Hongli Liu, Jiazhong Li*, Huanxiang Liu, Paola Gramatica, Combined Ligand/Structure-Based Virtual Screening and Molecular Dynamics Simulations of Steroidal Androgen Receptor Antagonists, Biomed Research International, 2017, Vol 2017, Article ID 3572394, 18 pages.

[4] Hongli Liu, Rui Han, Jiazhong Li*, Huanxiang Liu, Lifang Zheng, Molecular mechanism of R-bicalutamide switching from androgen receptor antagonist to agonist induced by amino acid mutations using molecular dynamics simulations and free energy calculation, Journal of Computer-Aided Molecular Design, 2016, 30, 1189–1200.

[5] Hongli Liu, Xiaoli An, Shuyan Li, Yuwei Wang, Jiazhong Li*, Huanxiang Liu, Interaction mechanism exploration of R-bicalutamide/S-1 with WT/W741L AR using molecular dynamics simulations, Molecular BioSystems, 2015, 11, 3347-3354.

[6] Jiazhong Li*, Fang Bai, Huanxiang Liu, Paola Gramatica. Ligand Efficiency Outperforms pIC50 on Both 2D MLR and 3D CoMFA Models: A Case Study on AR Antagonists. Chemical Biology & Drug Design, 2015, 86, 1501-1517.

[7] Yuwei Wang, Fang Bai, Hong Cao, Jiazhong Li*, Huanxiang Liu, Paola Gramatica. A Combined Quantitative Structure-Activity Relationship Research of Quinolinone Derivatives as Androgen Receptor Antagonists. Combinatorial Chemistry & High Throughput Screening, 2015, 18, 834-845.

[8] Jiazhong Li*, Xin Wang, Huanxiang Liu, Hongyu Li. In silico classification and prediction of VIP derivatives as VPAC1/VPAC2 receptor agonists/antagonists. Combinatorial chemistry & high throughput screening, 2015, 18, 33-41.

[9] Jiazhong Li*, Shuyan Li, Chongliang Bai, Huanxiang Liu, Paola Gramatica. Structural requirements of 3-carboxyl-4(1H)-quinolones as potential antimalarials from 2D and 3D QSAR analysis Journal of Molecular Graphics and Modelling, 2013, 44, 266–277.

[10] Jiazhong Li*, Huanxiang Liu, Xing Huo, Paola Gramatica. Structure-Activity Relationship Analysis of the Thermal Stabilities of Nitroaromatic Compounds Following Different Decomposition Mechanisms. Molecular Informatics, 2013, 32, 193-202.

[11] Xing Huo, Jiazhong Li*. Quantitative structure–activity relationship analysis of a novel series of chemicals antagonizing WT and MT AR. Chemometrics and Intelligent Laboratory Systems, 2011, 107 283-289.

[12] Jiazhong Li, Shuyan Li, Beilei Lei, Huanxiang Liu, Xiaojun Yao, Mancang Liu, Paola Gramatica, A new strategy to improve the predictive ability of the local lazy regression and its application to the QSAR study of melanin-concentrating hormone receptor 1 antagonists, Journal of Computational Chemistry, 2010, 31, 973-985.

[13] Jiazhong Li, Paola Gramatica, Classification and Identification of Androgen Receptor Antagonists with Various Methods and Consensus Approach, Journal of Chemical Information and Modeling, 2010, 50, 861-874.

[14] Jiazhong Li, Paola Gramatica, The importance of molecular structures, endpoints’ values, and predictivity parameters in QSAR research: QSAR analysis of a series of estrogen receptor binders, Molecular Diversity, 2010, 14, 687-696.

[15] Jiazhong Li, Paola Gramatica, QSAR classification of estrogen receptor binders and identification of pleiotropic EDCs, SAR & QSAR in Environmental Research, 2010, 21, 657-669.

【研究项目】

1. 国家自然科学基金青年基金(21205055)：抗CRPC前列腺癌的AR受体纯拮抗剂的设计、筛选与活性评价，负责人。

2. 甘肃省自然科学基金青年基金（2011GS04091）：甾体类雄激素受体拮抗剂作为前列腺癌治疗药物的研究，负责人。

3. 留学回国人员科技活动项目（第46批）：选择性雄激素受体调节剂（SARMs）的构效关系及作用机理研究，负责人。

4. 横向课题：枸杞鲜果真空冻干加工实验及成分分析研究，负责人。

5. 横向课题：枸杞精油、枸杞多糖有效成分分析及动物毒理实验研究，负责人。