张占欣

职务/职称：副教授/硕导

研 究 所：药物分析学研究所

电子邮件：zhangzhx@lzu.edu.cn

【基本情况】

本课题组一直从事中药及天然药物活性成分的研究工作。在对数十种中药及天然药物活性成分研究的过程中，发现了几百个天然化合物(其中新化合物60余个、新骨架结构化合物3个)，以及一些具有生物活性的先导化合物。主持国家自然科学基金面上项目1项，国家自然科学基金青年基金1项。已发表SCI收录研究论文40余篇，其中以第一作者或者通讯作者在Organic Letters, organic Chemistry Frontiers, RSC Advances, Fitoterapia, Planta Medica发表SCI研究论文26篇。讲授多门本科生和研究生课程。担任多个天然产物SCI杂志的审稿人。

【研究方向】

天然药物化学、天然产物化学、中草药与植物化学

【主讲课程】

承担药学专业本科生基础课《物理化学》课堂讲授

【研究成果】

近5年来以通讯及第一作者发表的SCI研究论文： 

[1] Ying-Hong Liu, Pei-Qian Wu, Qiao-Ling Hu, Yue-Juan Pei, Feng-Ming Qi, Zhan-Xin Zhang*, Dong-Qing Fei*, Cytotoxic and antibacterial activities of iridoids and sesquiterpenoids from Valeriana jatamansi, Fitoterapia, 2017, 123, 73-78. （SCI三区，IF= 2.698） 

[2] Zheng-Yu Li, Feng-Ming Qi, De-Juan Zhi, Qiao-Ling Hu, Ying-Hong Liu, Zhan-Xin Zhang*, Dong-Qing Fei*, A novel spirocyclic triterpenoid and a new taraxerane triterpenoid from Teucrium viscidum, organic Chemistry Frontiers, 2017, 4(1): 42-46 （SCI二区，IF= 4.955） 

[3] Dong-Qing Fei*, Le-Le Dong, Feng-Ming Qi, Gai-Xia Fan, Hui-Hong Li, Zheng-Yu Li, Zhan-Xin Zhang*, Euphorikanin a, a diterpenoid lactone with a fused 5/6/7/3 ring system from Euphorbia kansui, organic Letters, 2016, 18(12): 2844-2847 （SCI top 一区，IF= 6.579） 

[4] Gai-Xia Fan, Le-Le Dong, Hui-Hong Li, Zheng-Yu Li, Zhan-Xin Zhang*, Dong-Qing Fei*, Sesquiterpenoids and other chemical components from the roots of Dolomiaea souliei, Chemistry of Natural Compounds, 2016, 52(4): 754-757 

[5] Gai-Xia Fan, De-Juan Zhi, Hui Ren, Zheng-Yu Li, Qiao-Ling Hu, Ying-Hong Liu, Zhan-Xin Zhang*, Dong-Qing Fei*, A new succinate derivative from Ajuga decumbens, Natural Product Communications, 2016, 11(4): 497-498 

[6] Le-Le Dong, Hui-Yan Xiong, Feng-Ming Qi, Hui-Hong Li, Gai-Xia Fan, Jing-Min Che, Ding-Ding Guo, Zhan-Xin Zhang*, Dong-Qing Fei*, A new norsesquiterpenoid from Ligularia virgaurea, Journal of Asian Natural Products Research, 2015, 17(4): 415-419 

[7] Zhan-Xin Zhang*, Hui-Hong Li, Le-Le Dong, Gai-Xia Fan, Dong-Qing Fei*, Chemical constituents of the roots of Ligularia lapathifolia, Chemistry of Natural Compounds, 2015, 51(2): 375-377 

[8] Zhan-Xin Zhang*, Hui-Hong Li, Feng-Ming Qi, Le-Le Dong, Yang Hai, Gai-Xia Fan, Dong-Qing Fei*, Crocrassins A and B: two novel sesquiterpenoids with an unprecedented carbon skeleton from Croton crassifolius, RSC Advances, 2014, 4(57): 30059-30061 (SCI 三区，IF= 3.108) 

[9] Hui-Hong Li, Feng-Ming Qi, Le-Le Dong, Gai-Xia Fan, Jing-Min Che, Ding-Ding Guo, Zhan-Xin Zhang*, Dong-Qing Fei*, Cytotoxic and antibacterial pyran-2-one derivatives from Croton crassifolius, Phytochemistry Letters, 2014, 10: 304-308 

[10] Zhan-Xin Zhang*, Hui-Hong Li, Feng-Ming Qi, Hui-Yan Xiong, Le-Le Dong, Gai-Xia Fan, Dong-Qing Fei*, A new halimane diterpenoid from Croton crassifolius, Bulletin of the Korean Chemical Society, 2014, 35(5): 1556-1558 

[11] Zhan-Xin Zhang*, Feng-Ming Qi, Hui-Hong Li, Le-Le Dong, Yang Hai, Gai-Xia Fan, Dong-Qing Fei*, A new lathyrane diterpenoid from the whole plant of Euphorbia altotibetica, Bulletin of the Korean Chemical Society, 2014, 35(2): 641-643 

【研究项目】

主持国家自然科学基金面上项目1项，国家自然科学基金青年基金1项，中央高校基本科研业务费4项。